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Vaxcyte, Inc., a clinical-stage vaccine innovation company, develops conjugate and novel protein vaccines to prevent or treat bacterial infectious diseases. Its lead vaccine candidate is VAX-24, a 24-valent carrier-sparing investigational pneumococcal conjugate vaccine (PCV) for the prevention of invasive pneumococcal disease (IPD) in infants. The company also develops VAX-31, a 31-valent, carrier-sparing investigational PCV for the prevention of IPD in adults and children; VAX-A1, a novel conjugate vaccine candidate to prevent disease caused by Group A Streptococcus; VAX-PG, a novel protein vaccine candidate targeting the keystone pathogen responsible for periodontitis; VAX-GI, a novel preclinical vaccine candidate for the treatment of dysentery and shigellosis, which is caused by Shigella bacteria; and VAX-XL, a third-generation pneumococcal conjugate vaccine. The company was formerly known as SutroVax, Inc. and changed its name to Vaxcyte, Inc. in May 2020. Vaxcyte, Inc. was incorporated in 2013 and is headquartered in San Carlos, California.
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Vaxcyte is a clinical-stage biotechnology company developing vaccines using a proprietary platform, with a lead 24-valent pneumococcal conjugate vaccine candidate and a pipeline of additional vaccine programs. Long-term growth could be driven by late-stage progress and potential approval of its pneumococcal candidate, platform-enabled pipeline expansion, and in-house manufacturing capabilities that may support commercial scale and broader market access.
Key investment risks include clinical and regulatory failure for lead candidates, strong competition from incumbent vaccine manufacturers, and ongoing financing and commercialization execution challenges.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -766.63M | -463.93M | -402.27M | -223.49M | -100.08M |
| Net income | -766.63M | -463.93M | -402.27M | -239.64M | -100.08M |
| Selling general administrative | 129.37M | 92.90M | 60.70M | 39.81M | 25.26M |
| Selling and marketing expenses | - | - | 10.17M | - | - |
| Gross profit | - | -15.85M | -75.00M | - | - |
| Reconciled depreciation | 24.86M | 15.85M | 10.17M | 9.20M | 3.46M |
| Ebit | -766.63M | -463.93M | -402.27M | -232.26M | -103.67M |
| Ebitda | -741.77M | -448.08M | -392.10M | -189.78M | -98.28M |
| Depreciation and amortization | 24.86M | 15.85M | 10.17M | 42.48M | 5.39M |
| Non operating income net other | - | - | - | - | 3.59M |
| Operating income | -923.67M | -569.55M | -468.04M | -232.26M | -103.67M |
| Other operating expenses | 923.67M | 569.55M | 468.04M | 207.33M | 102.08M |
| Interest expense | - | 0.00M | 0.00M | 0.00M | 0.01M |
| Interest income | 119.72M | 109.99M | 62.91M | 8.36M | 0.34M |
| Net interest income | 119.72M | 109.99M | 62.91M | 8.35M | 0.34M |
| Income tax expense | - | - | -402.27M | 16.16M | 0.01M |
| Total revenue | 0.00M | 0.00M | 0.00M | 0.00M | 0.00M |
| Total operating expenses | 923.67M | 569.55M | 468.04M | 207.33M | 102.08M |
| Cost of revenue | - | 15.85M | 75.00M | - | - |
| Total other income expense net | 157.05M | 105.62M | 65.78M | 8.77M | 3.59M |
| Net income from continuing ops | -766.63M | -463.93M | -402.27M | -223.49M | -100.08M |
| Net income applicable to common shares | - | - | - | -223.49M | -100.08M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 3045.97M | 3511.32M | 1407.92M | 1006.18M | 324.34M |
| Other current assets | 19.84M | 20.11M | 12.12M | 11.18M | 10.38M |
| Total liab | 360.45M | 205.50M | 167.45M | 52.56M | 40.32M |
| Total stockholder equity | 2685.51M | 3305.82M | 1240.47M | 953.61M | 284.02M |
| Deferred long term liab | - | - | - | 0.50M | 0.50M |
| Other current liab | 128.72M | 85.84M | 123.64M | 24.82M | 16.68M |
| Common stock | 0.13M | 0.13M | 0.10M | 0.08M | 0.06M |
| Capital stock | 0.13M | 0.13M | 0.10M | 0.08M | 0.06M |
| Retained earnings | -2154.95M | -1388.32M | -924.39M | -522.13M | -298.64M |
| Other liab | - | - | - | 0.01M | 0.10M |
| Other assets | - | - | 0.00M | 5.43M | 4.96M |
| Cash | 173.96M | 387.88M | 397.45M | 834.66M | 68.98M |
| Total current liabilities | 205.75M | 140.18M | 145.34M | 40.52M | 28.72M |
| Net debt | 54.88M | -316.77M | -368.23M | -816.72M | -52.20M |
| Short term debt | 6.12M | 5.89M | 7.11M | 5.91M | 5.28M |
| Short long term debt total | 228.84M | 71.11M | 29.22M | 17.94M | 16.78M |
| Other stockholder equity | 4838.74M | 4697.88M | 2164.58M | 1476.02M | 258.51M |
| Property plant equipment | - | - | - | 31.65M | 35.91M |
| Total current assets | 1627.36M | 1787.98M | 1095.95M | 942.55M | 256.35M |
| Long term investments | 881.66M | 1387.51M | 162.68M | 26.55M | 27.12M |
| Net tangible assets | - | - | - | 953.61M | 284.02M |
| Short term investments | 1387.00M | 1359.33M | 682.78M | 96.72M | 176.99M |
| Net receivables | 46.56M | 20.66M | 3.61M | 1.00M | 1.20M |
| Accounts payable | 70.90M | 48.45M | 14.59M | 9.79M | 6.76M |
| Accumulated other comprehensive income | 1.59M | -3.87M | 0.18M | -0.36M | -0.24M |
| Common stock total equity | - | - | - | - | 0.06M |
| Retained earnings total equity | - | - | - | - | -298.64M |
| Non currrent assets other | 0.51M | 65.68M | 37.56M | 5.43M | 4.96M |
| Non current assets total | 1418.60M | 1723.33M | 311.96M | 63.62M | 67.99M |
| Capital lease obligations | 117.48M | 71.11M | 29.22M | 17.94M | 16.78M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | 494.33M | -2005.67M | -773.31M | 74.58M | -212.31M |
| Change to liabilities | - | - | - | 2.90M | -12.47M |
| Total cashflows from investing activities | 437.35M | -2005.67M | -773.31M | 74.58M | -212.31M |
| Total cash from financing activities | 2.01M | 2448.51M | 639.81M | 861.55M | 17.80M |
| Change to operating activities | - | - | - | 9.84M | -24.54M |
| Net income | -766.63M | -463.93M | -402.27M | -223.49M | -100.08M |
| Change in cash | -213.77M | -9.36M | -436.97M | 765.67M | -316.34M |
| Begin period cash flow | 389.19M | 398.55M | 835.53M | 69.86M | 386.20M |
| End period cash flow | 175.43M | 389.19M | 398.55M | 835.53M | 69.86M |
| Total cash from operating activities | -655.58M | -452.63M | -296.79M | -170.60M | -121.39M |
| Issuance of capital stock | 0.00M | 2435.66M | 636.04M | 856.48M | 13.90M |
| Depreciation | 24.86M | 15.85M | 10.17M | 9.20M | 3.46M |
| Other cashflows from investing activities | -43.26M | -96.73M | - | - | 0.03M |
| Sale purchase of stock | - | - | 2.04M | 1.03M | 0.89M |
| Other cashflows from financing activities | -10.99M | 12.85M | 3.77M | 4.03M | 3.01M |
| Change to netincome | - | - | - | 30.95M | 12.23M |
| Capital expenditures | 13.71M | 22.43M | 67.88M | 5.85M | 6.55M |
| Cash flows other operating | - | - | - | - | -30.68M |
| Cash and cash equivalents changes | - | - | - | - | -315.90M |
| Change in working capital | -3.45M | -54.90M | 81.32M | 12.74M | -37.01M |
| Stock based compensation | 138.84M | 84.82M | 48.76M | 23.65M | 10.73M |
| Other non cash items | -49.20M | -34.47M | -34.77M | 7.30M | 1.50M |
| Free cash flow | -669.29M | -475.05M | -364.67M | -176.44M | -127.95M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|
| PCVX Vaxcyte Inc |
2.26 3.41% |
68.62 | - | - | - | 3.21 | -14.43 |
| NVO Novo Nordisk A/S |
0.41 1.00% |
41.10 | 41.58 | 31.15 | 2.13 | 32.99 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
-0.86 0.16% |
547.03 | 30.22 | 24.27 | 10.36 | 6.50 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
43.35 4.73% |
959.41 | 29.07 | 20.12 | 7.57 | 3.82 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 36.06 |
Vaxcyte, Inc., a clinical-stage vaccine innovation company, develops conjugate and novel protein vaccines to prevent or treat bacterial infectious diseases. Its lead vaccine candidate is VAX-24, a 24-valent carrier-sparing investigational pneumococcal conjugate vaccine (PCV) for the prevention of invasive pneumococcal disease (IPD) in infants. The company also develops VAX-31, a 31-valent, carrier-sparing investigational PCV for the prevention of IPD in adults and children; VAX-A1, a novel conjugate vaccine candidate to prevent disease caused by Group A Streptococcus; VAX-PG, a novel protein vaccine candidate targeting the keystone pathogen responsible for periodontitis; VAX-GI, a novel preclinical vaccine candidate for the treatment of dysentery and shigellosis, which is caused by Shigella bacteria; and VAX-XL, a third-generation pneumococcal conjugate vaccine. The company was formerly known as SutroVax, Inc. and changed its name to Vaxcyte, Inc. in May 2020. Vaxcyte, Inc. was incorporated in 2013 and is headquartered in San Carlos, California.
| Name | Title | Year Born |
|---|---|---|
| Mr. Grant E. Pickering M.B.A. | Co-Founder, CEO & Director | 1968 |
| Mr. Andrew L. Guggenhime M.B.A. | Pres, CFO & Principal Accounting Officer | 1968 |
| Mr. James Wassil M.B.A., M.S. | Exec. VP & COO | 1969 |
| Mr. Paul W. Sauer M.B.A., MBA | Sr. VP of Process Devel. & Manufacturing | 1961 |
| Mr. Harp Dhaliwal M.B.A. | Sr. VP of Commercial Manufacturing & Supply Chain | 1973 |
| Dr. Ashish Khanna M.B.A., Ph.D. | Co-Founder and Chief Bus. Officer | 1972 |
| Dr. Jeff Fairman Ph.D. | Co-Founder & VP of Research | 1964 |
| Ms. Janet Graesser | VP of Corp. Communications & Investor Relations | NA |
| Mr. Mikhail Eydelman J.D. | Sr. VP, Gen. Counsel & Corp. Sec. | 1978 |
| Karen Alderete | Exec. Director of HR | NA |
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