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Beam Therapeutics Inc., a biotechnology company, engages in the development of precision genetic medicines for patients suffering from serious diseases in the United States. Its programs in hematology and genetic disease portfolio include Ristoglogene autogetemcel, a patient-specific, autologous hematopoietic stem cell (HSC) therapy for the treatment of sickle cell disease; BEAM-302, a liver-targeting lipid nanoparticle (LNP) for the treatment of severe alpha-1 antitrypsin deficiency; BEAM-304, a liver-targeting LNP for the treatment of phenylketonuria; and BEAM-301, a liver-targeting LNP formulation for the treatment of glycogen storage disease type 1a. The company also develops the ESCAPE platform, which combines antibody-based conditioning with multiplex gene edited HSCs. In addition, it develops BEAM-103, an anti-CD117 monoclonal antibody that enables ESCAPE. The company has research collaboration agreement with Pfizer Inc., focusing on in vivo base editing programs for targets rare genetic diseases of the liver, muscle, and central nervous system; Verve Therapeutics, Inc., for cardiovascular disease treatments; and Orbital Therapeutics to design RNA for the prevention, treatment, or diagnosis of human disease. Beam Therapeutics Inc. was incorporated in 2017 and is based in Cambridge, Massachusetts.
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Beam Therapeutics develops precision genetic medicines using base editing, a platform designed to make specific single-base DNA changes without introducing double-strand breaks. Its long-term growth drivers include platform expansion into both ex vivo and in vivo programs, progression of a diversified pipeline toward clinical proof-of-concept, and intellectual property around novel editors. Investors may find the company attractive because the technology appears positioned to address multiple monogenic diseases with an aim to improve safety and specificity versus earlier gene-editing approaches.
Principal risks are clinical and regulatory uncertainty, potential off-target or long-term safety issues unique to base editing, substantial cash burn and financing needs, and strong competition from other gene-editing and genetic-medicine developers.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -79.99M | -376.70M | -131.16M | -260.18M | -370.64M |
| Net income | -79.99M | -376.74M | -132.53M | -263.59M | -341.36M |
| Selling general administrative | 113.82M | 111.53M | 116.81M | 87.81M | 57.22M |
| Selling and marketing expenses | - | - | 20.01M | - | - |
| Gross profit | 117.45M | -304.04M | 377.71M | 60.92M | 51.84M |
| Reconciled depreciation | 22.29M | 31.59M | 18.59M | 14.15M | 7.45M |
| Ebit | -36.26M | -415.57M | -176.49M | -338.48M | -392.46M |
| Ebitda | -29.92M | -393.64M | -146.95M | -401.48M | -414.30M |
| Depreciation and amortization | 6.34M | 21.93M | 29.53M | -63.00M | -21.84M |
| Non operating income net other | - | - | - | - | 21.83M |
| Operating income | -383.69M | -415.57M | -176.49M | -338.48M | -392.46M |
| Other operating expenses | 523.44M | 479.09M | 554.19M | 399.40M | 444.31M |
| Interest expense | 43.73M | 49.09M | 46.68M | 15.30M | 0.01M |
| Tax provision | 0.00M | 0.04M | 1.00M | 3.41M | - |
| Net interest income | 43.73M | 49.09M | 42.22M | 15.30M | -0.01M |
| Income tax expense | - | 0.04M | 1.37M | 3.41M | -29.28M |
| Total revenue | 139.74M | 63.52M | 377.71M | 60.92M | 51.84M |
| Total operating expenses | 501.14M | 111.53M | 554.19M | 399.40M | 444.31M |
| Cost of revenue | 22.29M | 367.56M | 437.38M | - | - |
| Total other income expense net | 303.70M | 38.87M | 45.32M | 78.30M | 21.83M |
| Net income from continuing ops | -79.99M | -376.74M | -313.67M | -289.09M | -370.64M |
| Net income applicable to common shares | - | - | - | -260.18M | -370.64M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 1481.18M | 1103.82M | 1459.71M | 1341.71M | 1474.45M |
| Other current assets | 23.48M | 27.41M | 21.17M | 14.76M | 307.36M |
| Total liab | 242.82M | 370.28M | 478.38M | 608.24M | 647.72M |
| Total stockholder equity | 1238.36M | 733.54M | 981.33M | 733.47M | 826.74M |
| Other current liab | 65.68M | 37.78M | 121.98M | 68.21M | 112.15M |
| Common stock | 1.02M | 0.84M | 0.82M | 0.71M | 0.68M |
| Capital stock | 1.02M | 0.84M | 0.82M | 0.71M | 0.68M |
| Retained earnings | -1641.22M | -1566.63M | -1189.89M | -1057.36M | -768.27M |
| Other liab | - | - | - | 214.87M | 296.46M |
| Other assets | - | - | - | 14.69M | 14.47M |
| Cash | 294.94M | 281.97M | 435.89M | 232.77M | 965.65M |
| Total current liabilities | 96.94M | 182.07M | 205.56M | 223.59M | 213.44M |
| Current deferred revenue | 6.66M | 108.86M | 68.71M | 135.97M | 86.27M |
| Net debt | -1.06M | -120.54M | -262.72M | -53.76M | -823.30M |
| Short term debt | 14.36M | 13.47M | 13.26M | 10.38M | 7.54M |
| Short long term debt | - | - | - | - | 2.29M |
| Short long term debt total | 293.88M | 161.43M | 173.17M | 179.00M | 142.35M |
| Other stockholder equity | 2877.45M | 2298.66M | 2169.80M | 1792.55M | 119.92M |
| Property plant equipment | - | - | - | 234.13M | 186.98M |
| Total current assets | 1268.69M | 878.15M | 1211.04M | 1092.90M | 965.65M |
| Net tangible assets | - | - | - | 733.47M | 826.74M |
| Short term investments | 950.27M | 568.77M | 753.98M | 845.37M | 405.65M |
| Net receivables | - | - | - | 0.00M | 300.00M |
| Long term debt | - | - | - | - | 3.01M |
| Inventory | - | - | - | - | -607.36M |
| Accounts payable | 10.23M | 3.87M | 1.62M | 9.03M | 7.47M |
| Accumulated other comprehensive income | 1.11M | 0.68M | 0.60M | -2.43M | -0.05M |
| Common stock total equity | - | - | - | - | 0.68M |
| Retained earnings total equity | - | - | - | - | -768.27M |
| Non currrent assets other | 0.63M | 9.40M | 2.15M | 14.69M | 321.83M |
| Non current assets total | 212.49M | 225.68M | 248.67M | 248.82M | 508.81M |
| Capital lease obligations | 154.12M | 161.43M | 172.69M | 179.00M | 142.35M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | -361.56M | 185.01M | 87.18M | -461.34M | -247.95M |
| Change to liabilities | - | - | - | -33.55M | 348.97M |
| Total cashflows from investing activities | -121.44M | 185.01M | 71.84M | -461.34M | -294.14M |
| Net borrowings | 0.00M | -0.48M | -2.25M | -2.29M | -2.12M |
| Total cash from financing activities | 478.05M | 7.74M | 276.45M | 111.59M | 756.14M |
| Change to operating activities | - | - | - | -14.82M | -237.72M |
| Net income | -79.99M | -376.74M | -132.53M | -289.09M | -370.64M |
| Change in cash | 11.51M | -154.50M | 199.09M | -327.22M | 395.73M |
| Begin period cash flow | 290.11M | 444.61M | 245.52M | 572.74M | 177.01M |
| End period cash flow | 301.62M | 290.11M | 444.61M | 245.52M | 572.74M |
| Total cash from operating activities | -345.10M | -347.25M | -149.19M | 22.53M | -66.27M |
| Issuance of capital stock | 470.51M | 0.00M | 268.46M | 108.26M | 757.45M |
| Depreciation | 22.29M | 21.93M | 20.01M | 14.15M | 7.45M |
| Other cashflows from investing activities | 254.75M | -8.95M | - | - | 0.62M |
| Change to account receivables | - | - | -0.15M | 300.00M | -300.00M |
| Sale purchase of stock | - | - | - | - | 758.26M |
| Other cashflows from financing activities | - | 8.22M | 8.53M | 5.62M | 0.81M |
| Change to netincome | - | - | - | 16.93M | 185.66M |
| Capital expenditures | 14.95M | 8.95M | 33.73M | 48.95M | 46.81M |
| Cash flows other operating | - | - | - | - | 51.89M |
| Cash and cash equivalents changes | - | - | - | - | 395.73M |
| Change in working capital | -131.02M | -110.22M | -116.45M | 251.63M | 111.25M |
| Stock based compensation | 94.24M | 120.66M | 98.65M | 84.32M | 43.57M |
| Other non cash items | -250.63M | -2.87M | -18.87M | -38.48M | 158.86M |
| Free cash flow | -360.05M | -356.19M | -182.93M | -26.42M | -113.08M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| BEAM Beam Therapeutics Inc |
-1.06 4.11% |
24.75 | - | - | 22.56 | 2.59 | 15.17 | -7.03 |
| NVO Novo Nordisk A/S |
-0.54 1.32% |
40.55 | 41.58 | 31.15 | 2.13 | 32.99 | 2.11 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
-2.37 0.43% |
544.66 | 30.22 | 24.27 | 10.36 | 6.50 | 9.99 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
-2.77 0.29% |
956.64 | 29.07 | 20.12 | 7.57 | 3.82 | 6.95 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 11.38 | 36.06 |
Beam Therapeutics Inc., a biotechnology company, engages in the development of precision genetic medicines for patients suffering from serious diseases in the United States. Its programs in hematology and genetic disease portfolio include Ristoglogene autogetemcel, a patient-specific, autologous hematopoietic stem cell (HSC) therapy for the treatment of sickle cell disease; BEAM-302, a liver-targeting lipid nanoparticle (LNP) for the treatment of severe alpha-1 antitrypsin deficiency; BEAM-304, a liver-targeting LNP for the treatment of phenylketonuria; and BEAM-301, a liver-targeting LNP formulation for the treatment of glycogen storage disease type 1a. The company also develops the ESCAPE platform, which combines antibody-based conditioning with multiplex gene edited HSCs. In addition, it develops BEAM-103, an anti-CD117 monoclonal antibody that enables ESCAPE. The company has research collaboration agreement with Pfizer Inc., focusing on in vivo base editing programs for targets rare genetic diseases of the liver, muscle, and central nervous system; Verve Therapeutics, Inc., for cardiovascular disease treatments; and Orbital Therapeutics to design RNA for the prevention, treatment, or diagnosis of human disease. Beam Therapeutics Inc. was incorporated in 2017 and is based in Cambridge, Massachusetts.
| Name | Title | Year Born |
|---|---|---|
| Mr. John M. Evans M.B.A. | CEO & Director | 1978 |
| Dr. Giuseppe Ciaramella Ph.D. | Pres & Chief Scientific Officer | 1969 |
| Ms. Terry-Ann Burrell M.B.A. | CFO & Treasurer | 1977 |
| Dr. Feng Zhang Ph.D. | Co-Founder | NA |
| Dr. David R. Liu Ph.D. | Co-Founder | NA |
| Dr. J. Keith Joung M.D., Ph.D. | Co-Founder | NA |
| Dr. Nicole Gaudelli Ph.D. | Co-Founder | NA |
| Dr. Alexis Komor Ph.D. | Co-Founder | NA |
| Ms. Suzanne Fleming | Chief Accounting Officer | 1961 |
| Mr. Brian Riley | Sr. VP of Technical Operations | 1977 |
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