Key Highlights

  • 22nd Century Group (NASDAQ:XXII) slipped 16.56% to USD 0.0403 before a 1 for 58 reverse split that takes effect November 5, 2026.
  • Nuwellis (NASDAQ:NUWE) dropped 11.34% to USD 5.24 following a recent reverse split.
  • Shuttle Pharmaceuticals (NASDAQ:SHPH) lost 12.43% to USD 4.51 after a 1-for-10 split on June 11, 2026.
  • Zeta Network Group (NASDAQ:ZNB) declined 9.07% to USD 0.501 after an 8-for-1 split on July 27, 2026.
  • iPower (NASDAQ:IPW) shed 11.59% to USD 1.45 after a 1-for-12 split on October 26, 2026.

22nd Century Group (NASDAQ:XXII) (down USD 0.0080, 16.56%): Split Takes Effect Tomorrow

22nd Century Group (NASDAQ:XXII) fell 16.56% to USD 0.0403 in pre-market trading on November 4, 2026. The drop came after a regulatory filing dated November 3, 2026 that set a 1 for 58 reverse split effective at 12:01 a.m. Eastern Time on November 5, 2026. The company stated the split is intended only to bring its Nasdaq Capital Market listing back into compliance.

Shares outstanding would decline from 31,949,758 to roughly 550,858. Preliminary third quarter continuing operations Revenue came to about USD 4.8 million, compared with USD 2.9 million in the second quarter. These figures are unaudited and may change. Cash of USD 3.9 million set against a USD 2.6 million quarterly net loss keeps financing risk in focus, and as a Penny Stock the shares can move sharply.

Nuwellis (NASDAQ:NUWE) (down USD 0.6702, 11.34%): Giving Up Part of the Post-Split Gains

Nuwellis (NASDAQ:NUWE) slid 11.34% to USD 5.24 in pre-market trading on November 4, 2026, down from a USD 5.91 close on November 3. No company announcement dated November 3 or 4, 2026 was located, so the drop cannot be tied to a confirmed catalyst.

In a filing dated October 23, 2026, the company disclosed a reverse split with split-adjusted trading starting October 27, 2026, although the ratio was not in the materials reviewed. Second quarter 2026 revenue reached USD 1.97 million, up about 14%, with gross Margin of 76% and a net loss near USD 4.8 million. Cash stood at about USD 3.9 million on June 30, 2026, and the filing contained going-concern risk language.

Shuttle Pharmaceuticals (NASDAQ:SHPH) (down USD 0.6402, 12.43%): Frequent Capital Raises Sit Behind the Share Count

Shuttle Pharmaceuticals (NASDAQ:SHPH) dropped 12.43% to USD 4.51 in pre-market trading on November 4, 2026. The quote implies a prior close of about USD 5.15 (calculated). No company release, Earnings report or filing dated November 2, 3 or 4, 2026 was located, so the move is not linked to a confirmed cause.

The 1-for-10 reverse split took effect on June 11, 2026. A public offering on March 6, 2026 raised about USD 3.5 million gross, and a private Placement on November 3, 2025 brought in USD 2.5 million at an effective USD 4.00 per share. Trading as a penny stock with a history of small Equity raises, the company faces a real risk of further dilution.

Zeta Network Group (NASDAQ:ZNB) (down USD 0.0500, 9.07%): Slipping Back Under the Bid Price Threshold

Zeta Network Group (NASDAQ:ZNB) fell 9.07% to USD 0.501 in pre-market trading on November 4, 2026, from an implied prior close near USD 0.551 (calculated). No press release, filing or earnings report dated November 2 to November 4, 2026 was located, so there is no confirmed catalyst.

The 8-for-1 reverse share split started trading on July 27, 2026 as a step toward regaining compliance with Nasdaq Marketplace Rule 5550(a)(2). Class A shares outstanding dropped to about 969,859. At USD 0.501 the stock is again under the USD 1.00 bid price level, and no deficiency notice was located. Earlier offerings add dilution risk to this penny stock.

iPower (NASDAQ:IPW) (down USD 0.1901, 11.59%): Losing Ground After a Split and an AI Letter of Intent

iPower (NASDAQ:IPW) declined 11.59% to USD 1.45 in pre-market trading on November 4, 2026, from an implied prior close of about USD 1.64 (calculated). No company announcement dated November 2, 3 or 4, 2026 was located. The move follows a 1-for-12 reverse split effective October 26, 2026, which reduced shares from 6,394,999 to about 532,917.

A non-binding letter of intent dated October 15, 2026 pointed to up to USD 21.90 million in annualized fees at full build-out, and the company said this is not committed revenue, Backlog or guidance. Fiscal third quarter 2026 revenue was USD 3.50 million, compared with USD 16.04 million a year earlier, with a GAAP net loss of USD 3.45 million. Note conversions add dilution risk to this penny stock.

Where Things Stand

All five names dropped in pre-market trading on November 4, 2026, and each has a reverse split either in its recent history or immediately ahead. Only 22nd Century Group (NASDAQ:XXII) has a clear event in the same week, with its split effective November 5, 2026. The other four had no announcement identified. Investors should watch upcoming quarterly reports, Nasdaq correspondence and any new capital raises.