Sigma Healthcare (ASX:SIG), Neuren Pharmaceuticals (ASX:NEU) and Mesoblast (ASX:MSB) operate across pharmacy distribution and retail, rare-disease pharmaceuticals and cellular medicines. Their 2026 company updates covered financial performance, network expansion, Royalty income, regulatory activity, product commercialisation and clinical development.

Sigma Healthcare (ASX:SIG)

Sigma Healthcare operates pharmaceutical wholesale distribution, Franchise services and pharmacy retail activities. Its network includes Chemist Warehouse and My Chemist, with operations across Australia and international markets.

For FY26, Sigma reported Revenue of AUD 10.8 billion, an increase of 15.5%. Normalised EBIT reached AUD 1.09 billion, representing growth of 20.6%, while the normalised EBIT Margin was 10.1%. Normalised net profit after tax was AUD 732.3 million, up 22.3%.

The Australian segment recorded revenue growth of 14.9%, while international segment EBIT increased 91.3% to AUD 55.8 million. Sigma also reported AUD 32.6 million of integration synergies during FY26 and maintained its target of AUD 100 million in annual synergies by FY29. Net Debt was AUD 663 million, with debt representing 0.57 times normalised EBITDA.

Sigma Healthcare (ASX:SIG) also continued network expansion during FY26. Company disclosures reported further development of its domestic and international pharmacy operations alongside ongoing integration activities.

Neuren Pharmaceuticals (ASX:NEU)

Neuren Pharmaceuticals develops treatments for serious neurological conditions. Acadia Pharmaceuticals is Neuren's exclusive worldwide licensee for trofinetide, which is marketed as DAYBUE for Rett syndrome. Neuren also owns the NNZ-2591 development program.

In the second quarter of 2026, DAYBUE net sales reached USD 125 million, an increase of 24% from the first quarter of 2026. Neuren earned Q2 royalty income of USD 12.9 million. Following the quarter, Acadia increased its full-year 2026 DAYBUE net sales guidance to USD 480 million–USD 510 million, implying anticipated full-year royalty income for Neuren of USD 53 million–USD 56 million.

Neuren Pharmaceuticals (ASX:NEU) continued development of NNZ-2591 during 2026. Its Koala study is evaluating the therapy in Phelan-McDermid syndrome, while the company's development activities remain centred on neurological conditions with limited treatment options.

Mesoblast (ASX:MSB)

Mesoblast develops allogeneic cellular medicines. Its commercial portfolio includes Ryoncil, or remestemcel-L, for paediatric steroid-refractory acute graft-versus-host disease, alongside development programs covering other inflammatory and degenerative conditions.

Mesoblast released its annual financial results and operational update for the year ended 30 June 2026 on 27 August 2026. The company reported approximately USD 120.3 million in total revenue, including approximately USD 115.2 million of Ryoncil net revenue. Gross Profit was approximately USD 103.6 million. The net loss was approximately USD 57.5 million.

Ryoncil's commercial rollout expanded during FY26, with the company increasing the number of treatment centres using the therapy and extending payer coverage in the United States.

Healthcare Operations in 2026

Sigma's FY26 disclosures centred on revenue growth, pharmacy network operations and integration activity. The company reported AUD 10.8 billion of revenue and AUD 1.09 billion of normalised EBIT during the year.

Neuren's 2026 updates included DAYBUE quarterly sales and royalties, European regulatory developments and continuing development of NNZ-2591. DAYBUE generated Q2 2026 net sales of USD 125 million, with Neuren receiving USD 12.9 million in royalties for the quarter.

Mesoblast's FY26 update covered the first full financial year of Ryoncil commercial sales in the United States, together with continued clinical development across its cellular medicine portfolio.