Entropy Neurodynamics (ASX:ENP), a clinical-stage biotechnology company developing precision controlled psychedelic therapies, has amended its Constitution to reflect changes to employee share scheme provisions under Part 7.12 of the Corporations Act 2001 (Cth), following shareholder approval at the company's Annual General Meeting held on 12 November 2026.

Key Points

  • The Constitution has been amended to reflect changes to employee share scheme provisions under Part 7.12 of the Corporations Act 2001 (Cth).
  • A new clause 2.15 has been inserted, setting the issue cap for the Employee Incentive Plan at 10% under section 1100V(2) of the Corporations Act 2001 (Cth).
  • Shareholder approval for the amendments was obtained at the Annual General Meeting held on 12 November 2026.
  • The amended Constitution has been attached to the filing in accordance with ASX Listing Rule 15.4.2.

Constitutional Amendment Details

Entropy Neurodynamics disclosed that amendments to its Constitution have been made to reflect changes to employee share scheme provisions under Part 7.12 of the Corporations Act 2001 (Cth). The key amendment is the insertion of clause 2.15, which establishes the issue cap for the company's Employee Incentive Plan at 10% for the purposes of section 1100V(2) of the Corporations Act 2001 (Cth). The amended Constitution has been attached to the company's filing in accordance with ASX Listing Rule 15.4.2, the company stated.

Annual General Meeting Approval on 12 November 2026

According to the filing, the constitutional amendments follow shareholder approval obtained at the company's Annual General Meeting held on 12 November 2026. The amendments were authorised by the Board of Entropy Neurodynamics. The company is based in Melbourne, Australia, and describes itself as a clinical-stage biotechnology company focused on developing proprietary, novel formulations for the administration of psilocin in combination with psychotherapy to treat diseases with unmet medical needs.

Company's Lead Program and Clinical Background

The filing states that Entropy Neurodynamics' lead program, TRP-8803, is a proprietary formulation of IV-infused psilocin, described as the active metabolite of psilocybin. According to the filing, TRP-8803 has potential to significantly reduce the time to onset of the psychedelic state, control the depth and duration of the psychedelic experience, and reduce the overall duration of the intervention. The company disclosed that development of TRP-8803 follows a number of Phase 2a clinical trials using oral psilocybin for the treatment of Binge Eating Disorder, Irritable Bowel Syndrome, and Fibromyalgia.