Alterity Therapeutics (ASX: ATH) Completes Last Patient in ATH434-202 Phase 2 Trial for MSA

Thu 27 Mar 25, 03:23 AM |

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Highlights

Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE), a biotechnology company focused on developing disease-modifying treatments for neurodegenerative diseases, has announced the completion of clinical evaluations for the last patient in its ATH434-202 Phase 2 trial. This open-label study is designed to assess the safety, efficacy, and target engagement of the company’s drug candidate, ATH434, in patients with advanced multiple system atrophy (MSA).

The ATH434-202 trial involved 10 participants with advanced MSA, a progressive neurodegenerative disorder that severely impacts motor and autonomic functions. Participants received 75 mg doses of ATH434 for 12 months. The study’s primary objective is to evaluate the impact of treatment on brain volume, a key biomarker for MSA, and to assess other factors such as neuroimaging, protein biomarkers, and safety. These biomarkers, which include brain volume, iron levels, and aggregating α-synuclein, are central to the pathology of MSA and are critical for determining drug activity.

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